The Larracuente lab is hiring! Follow the link to find out more: joining the lab.
PI: Amanda Larracuente
Graduate Students: Emerson Khost, Ching-Ho Chang, John Bettinger (rotating) Xiaolu Wei (rotating)
Research associates and technicians: Danna Eickbush, Shaun Jones
Undergraduates: Arif Kodza, Linhe Xu (Alex), Thanatcha Khunkhet (Kwan), Danielle Pascua
Former lab members
Amanda earned her Ph.D. studying Drosophila genomics and sex chromosome evolution in Dr. Andrew Clark’s lab at Cornell University. During her postdoctoral training, she focused on the evolution of selfish DNA including the Segregation Distorter system of Drosophila melanogaster.
- Larracuente, A.M. 2014. The organization and evolution of the Responder satellite in species of the Drosophila melanogaster group: dynamic evolution of a target of meiotic drive. BMC Evol. Biol.14:233. doi:10.1186/s12862-014-0233-9
- Larracuente, A.M. and A.G. Clark. 2014. Recent selection on the Y-to-dot translocation in Drosophila pseudoobscura. Mol. Biol. Evol. 31(4):846-856. doi 10.1093/molbev/msu002.
- Larracuente, A.M. and A.G. Clark. 2013. Surprising differences in the variability of Y chromosomes in African and Cosmopolitan populations of Drosophila melanogaster. Genetics. 193:201-214.
- Larracuente, A.M. and D.C. Presgraves. 2012. The selfish Segregation Distorter gene complex of Drosophila melanogaster. Genetics. 192: 1-21.
Emerson is a 2nd-year EEB student working on the evolution and functional genomics of satellite DNA in Drosophila species. He is using deep real time single molecule sequencing from Pacific Biosciences to study the structural organization of satellite DNA loci in Drosophila genomes. Learn more about Emerson in his “Spotlight” article.
- Khost, D.E., D. Eickbush, A.M. Larracuente. Single molecule long read sequencing resolves the detailed structure of complex satellite DNA loci in Drosophila melanogaster. bioRxiv. 5/18/2016. http://dx.doi.org/10.1101/054155.
Ching-Ho is working on Segregation Distorter in Drosophila melanogaster and Y/dot chromosome evolution in Drosophila pseudoobscura. Before coming to Rochester, Ching-Ho worked with Dr. Chau-Ti Ting at National Taiwan University on neo-sex chromosome evolution in Drosophila albomicans. Ching-Ho is a recipient of the Ernst Caspari Fellowship.
- Chang, C-H. and A.M. Larracuente. 2016. Structural changes following the reversal of a Y chromosome to an autosome in Drosophila pseudoobscura. BIORXIV/2016/058412. 6/10/2016. http://dx.doi.org/10.1101/058412
- Chang C-c, Ting C-T, Chang C-H, Fang S, Chang H-y (2014) The Persistence of Facultative Parthenogenesis in Drosophila albomicans. PLoS ONE 9(11): e113275. doi:10.1371/journal.pone.0113275
- Chia-Hao Cheng, Ching-Ho Chang, and Hwei-yu Chang (2011) Early-stage evolution of the neo-Y chromosome in Drosophila albomicans. Zoological Studies 50(3): 338-349.
Danna Eickbush attended the University of Arizona where she was introduced to the wonders of molecular biology and immediately transferred to the newly formed Department of Cellular and Development Biology. She then joined the Ph.D. program in Cellular and Development Biology at Harvard University, characterizing the molecular structure and transcriptional patterns of the 71C-E region of Drosophila melanogaster while in the lab of Dr. Peter Cherbas. After moving to upstate New York, she did a postdoc with Dr. Jack Werren studying the selfish B-chromosome Paternal Sex Ratio (PSR) in the wasp Nasonia vitripennis. For the last 25 years, she has worked as a research associate with Dr. Tom Eickbush at the University of Rochester. The long tenure with her husband allowed Danna to study many aspects of the life cycle of the retrotransposable element R2, including its regulation and transcription. Danna works on the regulation of satellite DNA expression in Drosophila species.
Selected recent publications. Click here to see Danna’s PubMed list.
- Eickbush, T.H. and Eickbush, D.G. 2015. Integration, regulation, and long-term stability of R2 retrotransposons. In Mobile DNA III. ASMscience. Editor Nancy L. Craig (in Press).
- Eickbush, D.G., Burke, W.D. and Eickbush, T.H. 2013. Evolution of the R2 retrotransposon ribozyme and its self-cleavage site. PLoS One 8: e66441.
- Eickbush, D.G. and Eickbush, T.H. 2012. R2 and R2/R1 hybrid non-autonomous retrotransposons derived by internal deletions of full-length elements. Mobile DNA 3: 10.
Danielle Pascua (undergraduate)
Danielle is an undergraduate technician helping with fly crosses.
Thanatcha Khunkhet (Kwan, undergraduate)
Kwan is studying the functional genomics of satellite DNA.
Linhe Xu (Alex; undergraduate)
Alex is working on the regulation of satellite DNA expression in Drosophila melanogaster.
Arif is an intern in the lab studying the population genetics of satellite DNAs in Drosophila genomes.
Former lab members
Undergraduates: Jin Ho Kim , Riley O’Sullivan, Mackenzie Lee, Christian Silva
Graduate students: Steven Messer (rotating graduate student)