Journal club paper for 1/26/16

Please join us for journal club this week. We’ll be talking about R2D2 and meiotic drive in mice. Emerson Khost will present the following paper:
A Multi-Megabase Copy Number Gain Causes Maternal Transmission Ratio Distortion on Mouse Chromosome 2


If you have an idea to share, topic to discuss or just want to let the group know about an exciting paper, then please add comment below. If you have a slide to add to the rapid fire session, please e-mail it to Amanda ( before 12pm on Tuesday 1/26.


Journal Club, Fall 2015

This Fall’s journal club will be hosted by Dan Garrigan and focus on Epistasis and Speciation. This semester we will review the importance of genetic interactions in the evolution of postzygotic isolation, from both a theoretical and empirical perspective. Check back for weekly readings!

Journal Club 4/21: Balancing Selection

This week we’ll be reading about the maintenance of variation through balancing selection:

Bergland AO, Behrman EL, O’Brien KR, Schmidt PS, Petrov DA. 2014. Genomic evidence of rapid and stable adaptive oscillation over seasonal time scales in Drosophila. PLoS Genet. 10(11): e1004775.

Turchin MC, Chiang CWK, Palmer CD, Sankararaman S, Reich D, GIANT Consortium, Hirschhorn JN. 2012. Evidence of widespread selection on standing variation in Europe at height-associated SNPs. Nat. Genet. 44(9): 1015-1021.

Journal Club 3/3: Human GWAS

Next week we will be reading two papers about GWAS in humans, including one empirical paper that’s been cited over 3,000 times, and a thoughtful short perspective.

Burton, PR, Clayton, DG, Cardon, LR, Craddock, N, Deloukas, P, Duncanson, et al. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 447(7145): 661-678.

Goldstein, DB. (2009). Common genetic variation and human traits. New England Journal of Medicine. 360(17): 1696.