Please join us for EEB journal club Tuesday 2/16 at 12:30 in HH316 where Ching-Ho will discuss a recent paper on centromeres in Candida tropicalis: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005839.

Please join us Tuesday in HH316 at 12:30pm for Journal Club. This week, Rome is presenting this pair of papers on “supergenes” in ants:

http://www.nature.com/nature/journal/v493/n7434/full/nature11832.html
http://www.cell.com/current-biology/abstract/S0960-9822%2814%2901267-6

Please join us this week for Journal club where Steve will present a paper on the genomics of social parasitism in ants: http://mbe.oxfordjournals.org/content/32/11/2919.

If you have a topic to discuss, please comment below. If you have a slide to share, please e-mail Amanda (alarracu@bio.rochester.edu) by noon on Tuesday.

Please join us for journal club this week. We’ll be talking about R2D2 and meiotic drive in mice. Emerson Khost will present the following paper:
A Multi-Megabase Copy Number Gain Causes Maternal Transmission Ratio Distortion on Mouse Chromosome 2
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004850

If you have an idea to share, topic to discuss or just want to let the group know about an exciting paper, then please add comment below. If you have a slide to add to the rapid fire session, please e-mail it to Amanda (alarracu@bio.rochester.edu) before 12pm on Tuesday 1/26.

This Fall’s journal club will be hosted by Dan Garrigan and focus on Epistasis and Speciation. This semester we will review the importance of genetic interactions in the evolution of postzygotic isolation, from both a theoretical and empirical perspective. Check back for weekly readings!

This week we’ll be reading about the maintenance of variation through balancing selection:

Bergland AO, Behrman EL, O’Brien KR, Schmidt PS, Petrov DA. 2014. Genomic evidence of rapid and stable adaptive oscillation over seasonal time scales in Drosophila. PLoS Genet. 10(11): e1004775.

Turchin MC, Chiang CWK, Palmer CD, Sankararaman S, Reich D, GIANT Consortium, Hirschhorn JN. 2012. Evidence of widespread selection on standing variation in Europe at height-associated SNPs. Nat. Genet. 44(9): 1015-1021.

We will be discussing copy number variation in humans in journal club next week:

Perry et al. (2007) Diet and the evolution of human amylase gene copy number variation. Nature Genetics 39, 1256 – 1260

Sailani et al. (2013) The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome. Genome Res. 23(9):1410-21

Next week we will be discussing two papers on epistasis and quantitative variation in Drosophila:

Wen et al. (2012) Epistasis dominates the genetic architecture of Drosophila quantitative traits. PNAS 109 (39) 15553-15559.

Ober et al. (2012) Using Whole-Genome Sequence Data to Predict Quantitative Trait Phenotypes in Drosophila melanogaster. PLoS Genet 8(5): e1002685.

Next week we will be reading two papers on fluctuation selection and natural selection in humans:
Robinson et al. 2008. Environmental Heterogeneity Generates Fluctuating Selection on a Secondary Sexual Trait. Current Biology 18(10): 751–757
Milot et al. 2011. Evidence for evolution in response to natural selection in a contemporary human population. PNAS 108(41): 17040–17045

Next week we will be reading two papers about GWAS in humans, including one empirical paper that’s been cited over 3,000 times, and a thoughtful short perspective.

Burton, PR, Clayton, DG, Cardon, LR, Craddock, N, Deloukas, P, Duncanson, et al. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 447(7145): 661-678.

Goldstein, DB. (2009). Common genetic variation and human traits. New England Journal of Medicine. 360(17): 1696.