The topic of discussion for this week’s journal club is: Cell selection — Multicellular organisms and Cancer. We are reading Tao et al. 2011 paper entitled ‘Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data’
An additional review on this topic by Greaves and Maley (2012) ‘Clonal evolution in cancer‘ will also be discussed.
We are reading Fishman and Saunders 2008 Science paper titled ‘Centromere-Associated Female Meiotic Drive Entails Male Fitness Costs in Monkeyflowers’ for the 3/6 Journal Club. We are also reading an additional review on this topic by Malik and Henikoff (2009) ‘Major evolutionary transitions in centromere complexity.’
Check out this month’s TREE featured review ‘What do we need to know about speciation?”. In the age of ‘consortia of consortium’, speciation research is not alone. This article comes from a network of speciation researchers in Europe called the ‘The Marie Curie SPECIATION network’ – an initiative to train nine PhD level researchers in the area of speciation genetics in four different universities in Europe.
Now that we are done with the papers that gave us a perspective on the body and development of the theory of adaptation, we are moving to focus more on the data, generated over the past few decades, to assess this body of theory with empirical findings. As the first paper in this series, we are reading Orr and Coyne (1992) review that appeared in The American Naturalist — The Genetics of Adaptation: A reassessment.
We are reading Boughman’s 2001 Nature paper on “Divergent sexual selection enhances reproductive isolation in sticklebacks” for 4/19 journal Club [doi link].
We are reading Des Marais and Rausher paper titled ‘Escape from adaptive conflict after duplication in an anthocyanin pathway gene’ for 4/12 journal club. Mahul from Fry lab will lead the discussion.
We’ll be reading Seehausen et al. paper titled ‘Speciation through sensory drive in cichlid fish’ for this weeks’ journal club. Jing Zhu from Fry lab will lead the discussion.