{"id":756,"date":"2015-01-28T18:55:30","date_gmt":"2015-01-28T18:55:30","guid":{"rendered":"http:\/\/blogs.rochester.edu\/larracuente\/?page_id=756"},"modified":"2019-02-03T19:36:06","modified_gmt":"2019-02-03T19:36:06","slug":"the-functional-and-evolutionary-genomics-of-satellite-dna","status":"publish","type":"page","link":"http:\/\/blogs.rochester.edu\/larracuente\/the-functional-and-evolutionary-genomics-of-satellite-dna\/","title":{"rendered":"The functional and evolutionary genomics of satellite DNA"},"content":{"rendered":"<p>Satellite DNAs make up a large fraction of eukaryotic genomes and have important functions in chromosome pairing and segregation. The rapid evolution of satellite DNAs is a major force contributing to genome evolution across taxa and is implicated in genetic incompatibilities between species.<\/p>\n<figure id=\"attachment_1452\" aria-describedby=\"caption-attachment-1452\" style=\"width: 178px\" class=\"wp-caption alignright\"><a href=\"https:\/\/blogs.rochester.edu\/larracuente\/wp-content\/uploads\/2015\/01\/m12zoom_AAGAG_Rsp_RGB-copy.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1452 \" src=\"https:\/\/blogs.rochester.edu\/larracuente\/wp-content\/uploads\/2015\/01\/m12zoom_AAGAG_Rsp_RGB-copy-300x277.jpg\" alt=\"LarracuentRspAAGAG\" width=\"178\" height=\"164\" srcset=\"https:\/\/blogs.rochester.edu\/larracuente\/wp-content\/uploads\/2015\/01\/m12zoom_AAGAG_Rsp_RGB-copy-300x277.jpg 300w, https:\/\/blogs.rochester.edu\/larracuente\/wp-content\/uploads\/2015\/01\/m12zoom_AAGAG_Rsp_RGB-copy-1024x947.jpg 1024w, https:\/\/blogs.rochester.edu\/larracuente\/wp-content\/uploads\/2015\/01\/m12zoom_AAGAG_Rsp_RGB-copy.jpg 1045w\" sizes=\"auto, (max-width: 178px) 100vw, 178px\" \/><\/a><figcaption id=\"caption-attachment-1452\" class=\"wp-caption-text\">Drosophila melanogaster mitotic chromosomes showing the locations of the Rsp (red) and AAGAG (green) satellites.<\/figcaption><\/figure>\n<p>We use genomic, molecular and cytological techniques to study the forces driving the rapid divergence at satellite repeats in <em>Drosophila<\/em> populations and across <em>Drosophila<\/em> species. By developing methods to quantify satellite repeats using next generation sequencing and other molecular approaches, we have the ability to study the dynamics of satellite DNA evolution on a fine time scale.<\/p>\n<p>The misregulation of satellite DNA is linked to genome instability, some cancers, and hybrid dysgenesis. We currently know little about the regulation of satellite DNA and the origin of satellite-derived RNAs. We use molecular, genomic and cytological approaches to study the expression and maintenance of satellite DNA across <em>Drosophila<\/em> species.<\/p>\n<p>This work is supported by an NIH MIRA (NIGMS) award to AML.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Satellite DNAs make up a large fraction of eukaryotic genomes and have important functions in chromosome pairing and segregation. The rapid evolution of satellite DNAs is a major force contributing to genome evolution across taxa and is implicated in genetic incompatibilities between species. We use genomic, molecular and cytological techniques to study the forces driving &hellip; <a href=\"http:\/\/blogs.rochester.edu\/larracuente\/the-functional-and-evolutionary-genomics-of-satellite-dna\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">The functional and evolutionary genomics of satellite DNA<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":26,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-756","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.rochester.edu\/larracuente\/wp-json\/wp\/v2\/pages\/756","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.rochester.edu\/larracuente\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.rochester.edu\/larracuente\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.rochester.edu\/larracuente\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.rochester.edu\/larracuente\/wp-json\/wp\/v2\/comments?post=756"}],"version-history":[{"count":9,"href":"https:\/\/blogs.rochester.edu\/larracuente\/wp-json\/wp\/v2\/pages\/756\/revisions"}],"predecessor-version":[{"id":7502,"href":"https:\/\/blogs.rochester.edu\/larracuente\/wp-json\/wp\/v2\/pages\/756\/revisions\/7502"}],"wp:attachment":[{"href":"https:\/\/blogs.rochester.edu\/larracuente\/wp-json\/wp\/v2\/media?parent=756"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}