Recent publications from our lab

Monitoring the 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) modification in eukaryotic tRNAs via the gamma-toxin endonuclease.
Lentini JM, Ramos J, Fu D.
RNA (New York, N.Y.). 2018 PMID: 29440318

Elp3 and RlmN: A tale of two mitochondrial tail-anchored radical SAM enzymes in Toxoplasma gondii.
Padgett LR, Lentini JM, Holmes MJ, Stilger KL, Fu D, Sullivan WJ Jr.
PloS one. 2018; 13(1):e0189688. PMID:29293520

TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival.
Dewe JM, Fuller BL, Lentini JM, Kellner SM, Fu D.
Molecular and cellular biology. 2017; 37(21). PMID:28784718

ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage.
Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D.
Cell death & disease. 2017; 8(7):e2947 PMID:28726787

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.
Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS.
The Journal of biological chemistry. 2016; 291(38):20188-97.PMID:27510037

The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.
Fu D, Samson LD, Hübscher U, van Loon B.
DNA repair. 2015; 35:13-8. PMID:26408825

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