Publications

  1. Shaheen R, Mark P, Prevost CT, AlKindi A, Alhag A, Estwani F, Al-Sheddi T, Alobeid E, Alenazi MM, Ewida N, Ibrahim N, Hashem M, Abdulwahab F, Bryant EM, Spinelli E, Millichap J, Barnett SS, Kearney HM, Accogli A, Scala M, Capra V, Nigro V, Fu D, Alkuraya FS. Biallelic variants in CTU2 cause DREAM-PL syndrome and impair thiolation of tRNA wobble U34. Hum Mutat. 2019 Jul 13;. doi: 10.1002/humu.23870. [Epub ahead of print] PubMed PMID: 31301155.
  2. Ramos J, Han L, Li Y, Hagelskamp F, Kellner SM, Alkuraya FS, Phizicky EM, Fu D. Formation of tRNA wobble inosine in humans is disrupted by a millennia-old mutation causing intellectual disability. Mol Cell Biol. 2019 Jul 1;. doi: 10.1128/MCB.00203-19. [Epub ahead of print] PubMed PMID: 31263000.
  3. Ramos J, Fu D. The emerging impact of tRNA modifications in the brain and nervous system. Biochim Biophys Acta Gene Regul Mech. 2019 Mar;1862(3):412-428. doi: 10.1016/j.bbagrm.2018.11.007. Epub 2018 Dec 5. Review. PubMed PMID: 30529455.
  4. Gu C, Ramos J, Begley U, Dedon PC, Fu D, Begley TJ. Phosphorylation of human TRM9L integrates multiple stress-signaling pathways for tumor growth suppression. Sci Adv. 2018 Jul;4(7):eaas9184. doi: 10.1126/sciadv.aas9184. eCollection 2018 Jul. PubMed PMID: 30009260; PubMed Central PMCID: PMC6040840.
  5. Lentini JM, Ramos J, Fu D. Monitoring the 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) modification in eukaryotic tRNAs via the γ-toxin endonuclease. RNA. 2018 May;24(5):749-758. doi: 10.1261/rna.065581.118. Epub 2018 Feb 13. PubMed PMID: 29440318; PubMed Central PMCID: PMC5900570.
  6. Padgett LR, Lentini JM, Holmes MJ, Stilger KL, Fu D, Sullivan WJ Jr. Elp3 and RlmN: A tale of two mitochondrial tail-anchored radical SAM enzymes in Toxoplasma gondii. PLoS One. 2018;13(1):e0189688. doi: 10.1371/journal.pone.0189688. eCollection 2018. PubMed PMID: 29293520; PubMed Central PMCID: PMC5749711.
  7. Dewe JM, Fuller BL, Lentini JM, Kellner SM, Fu D. TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival. Mol Cell Biol. 2017 Nov 1;37(21). doi: 10.1128/MCB.00214-17. Print 2017 Nov 1. PubMed PMID: 28784718; PubMed Central PMCID: PMC5640816.
  8. Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D. ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage. Cell Death Dis. 2017 Jul 20;8(7):e2947. doi: 10.1038/cddis.2017.343. PubMed PMID: 28726787; PubMed Central PMCID: PMC5550884.
  9. Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS. Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling. J Biol Chem. 2016 Sep 16;291(38):20188-97. doi: 10.1074/jbc.M116.738799. Epub 2016 Aug 10. PubMed PMID: 27510037; PubMed Central PMCID: PMC5025701.

    Postdoctoral

  10. Fu D, Samson LD, Hübscher U, van Loon B. The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants. DNA Repair (Amst).2015 Nov;35:13-8. doi: 10.1016/j.dnarep.2015.09.008. Epub 2015 Sep 14. PubMed PMID: 26408825; PubMed Central PMCID: PMC5206904.
  11. Fu D, Jordan JJ, Samson LD. Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis.Genes Dev. 2013 May 15;27(10):1089-100. doi: 10.1101/gad.215533.113. Epub 2013 May 10. PubMed PMID: 23666923; PubMed Central PMCID: PMC3672644.
  12. Fu D, Calvo JA, Samson LD. Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer.2012 Jan 12;12(2):104-20. doi: 10.1038/nrc3185. Review. PubMed PMID: 22237395; PubMed Central PMCID: PMC3586545.
  13. Fu D, Samson LD. Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase. DNA Repair (Amst). 2012 Jan 2;11(1):46-52. doi: 10.1016/j.dnarep.2011.10.004. Epub 2011 Nov 11. PubMed PMID: 22079122; PubMed Central PMCID: PMC3253959.
  14. Fu D, Brophy JA, Chan CT, Atmore KA, Begley U, Paules RS, Dedon PC, Begley TJ, Samson LD. Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Mol Cell Biol. 2010 May;30(10):2449-59. doi: 10.1128/MCB.01604-09. Epub 2010 Mar 22. PubMed PMID: 20308323; PubMed Central PMCID: PMC2863699.

    Graduate

  15. Errington TM, Fu D, Wong JM, Collins K. Disease-associated human telomerase RNA variants show loss of function for telomere synthesis without dominant-negative interference. Mol Cell Biol. 2008 Oct;28(20):6510-20. doi: 10.1128/MCB.00777-08. Epub 2008 Aug 18. PubMed PMID: 18710936; PubMed Central PMCID: PMC2577424.
  16. Fu D, Collins K. Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol Cell. 2007 Dec 14;28(5):773-85. doi: 10.1016/j.molcel.2007.09.023. PubMed PMID: 18082603; PubMed Central PMCID: PMC2917595.
  17. Fu D, Collins K. Human telomerase and Cajal body ribonucleoproteins share a unique specificity of Sm protein association. Genes Dev. 2006 Mar 1;20(5):531-6. doi: 10.1101/gad.1390306. Epub 2006 Feb 15. PubMed PMID: 16481465; PubMed Central PMCID: PMC1410806.
  18. Fu D, Collins K. Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs. Mol Cell. 2003 May;11(5):1361-72. PubMed PMID: 12769858.

    Undergraduate and Post-baccalaureate

  19. Xiao H, Sandaltzopoulos R, Wang HM, Hamiche A, Ranallo R, Lee KM, Fu D, Wu C. Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions. Mol Cell. 2001 Sep;8(3):531-43. PubMed PMID: 11583616.
  20. Payne WE, Kaiser CA, Bevis BJ, Soderholm J, Fu D, Sears IB, Glick BS. Isolation of Pichia pastoris genes involved in ER-to-Golgi transport. Yeast. 2000 Aug;16(11):979-93. doi: 10.1002/1097-0061(200008)16:11<979::AID-YEA594>3.0.CO;2-C. PubMed PMID: 10923020.